Evidence Based article writing

Running head: ARIPIPRAZOLE USE 1
Student’s Name
University Affiliation
Aripiprazole is an antipsychotic drug that is usually recommended and exclusively used
in the treatment of bipolar disorder and schizophrenia. The drug can also be used as an add-on
treatment for most depressive disorders and irritability linked to autism. The article contains
guidance for practitioners as they administer aripiprazole to adolescents who suffer from
moderate to severe manic episodes associated with bipolar I disorder. Bipolar disorder is
characterized by fluctuations in moods polarity with manic and major depressive periods
alternatively. It is useful to medical practitioners since it provides a guideline for the
administration of this drug (Muneer 2016). By using the article, medical practitioners will be
able to issue dosing instructions and inform patients of the side effects of the drug when they use
it. It is important to medical nursing since it provides key insights regarding the treatment of
manic episodes in bipolar I disorder patients,
Summary of article
Aripiprazole is the preferred option for treating cases of mania in adolescents suffering
from bipolar I disorder. The drug has a marketing authorization of up to twelve weeks clinicians
are also advised to consider stopping treatment using the drug when usage hits the twelfth week.
The article also suggests that children should be involved in the matters concerning their taking
of drugs and assume responsibility.
The dosing instructions for aripiprazole require that only 10mg per day of the drug be
administered once without considering meals. This is the recommended dosage. However, there
are instances where patients take more than the recommended dosage. As such it is
recommended that the administration of such high doses of the drug should only be administered
in exceptional cases albeit under close clinical monitoring. Aripiprazole is packaged in different
weight distribution sizes as tablets and can also be found as an oral solution. The oral solutions
are bioequivalent. The drug's half-life is at least seventy-five hours. The drug has side effects
which rage form fatigue, somnolence and increased heart rate and weight.
Use of information from the article
As a medical practitioner, this information is vital in the treatment of bipolar I patients
who suffer from severe and mild manic episodes. The information initially provides instructions
to clinicians on how they should administer aripiprazole to bipolar patients.
The guideline holds the views of NICE and the views were arrived at after a careful
analysis of the evidence presented. Healthcare professional is therefore required to implement
the article’s findings when they indulge in clinical practices and exercise their judgment. The
guideline, however, does not supersede clinicians’ responsibilities in caring for patients.
Therefore, health professionals are still expected to make decisions that impact positively on the
health care of mental patients.
Strengths of the article
The article is quite significant in disseminating information about the use of aripiprazole
in treating manic episodes in patients. The guideline clearly outlines the instructions and
requirements that determine the administration of aripiprazole. This is very important for health
professionals. Moreover, the guideline in the article advices clinicians on regulating the use of
this drug which has a twelve-week maximum period use.
Weaknesses of the article
The article, unfortunately, does not provide sufficient details concerning the methods and
results that were used to make the finding. This is undesirable for an article providing facts about
a medical issue. The use of aripiprazole to treat bipolar I disorder has not been extensively
explored. The drug is known to have many complex issues surrounding its use. It is also common
knowledge that the drug's side effects can be deadly yet the article fails to reveal this unfortunate
reality ("Aripiprazole Uses, Side Effects & Warnings - Drugs.com", 2018).
The article also fails to carry out clinical trials to show the effectiveness of using the
drug. This would be significant since it would allow health practitioners to prove the results of
the findings in the article. The trials would also prove instrumental in showing evidence of how
the drug works in adolescents and encourage research into its use for younger bipolar patients.
I would highly recommend this article to a colleague for analysis and implementation in
their medical practices. This is because the article is quite informative of the guidelines used in
administering patient care to bipolar patients. The article is also quite instructive and advice
medical practitioners on how to deal with young bipolar patients. This makes it quite significant
to health professionals hence recommendable to my colleagues.
Bipolar disorder is a much neglected mental illness, and it has not been researched
extensively. This, therefore, introduces a perception that its treatment should be researched and
improved (Goodwin et al. 2016). The use of guidelines has provided medical practitioners the
opportunity to improve the quality of care by advocating for the implementation of particular
treatment approaches.
Therefore, in this article, it is quite important for medical practitioners to consider the use
of aripiprazole in the treatment of manic episodes. By adhering to the laid out guidelines, they
will be able to support patient care to adolescents over the age of thirteen years who suffer from
manic episodes. More importantly, the guideline will assist medical practitioners in ensuring the
treatment plan works efficiently.
(2018). Dorsetccg.nhs.uk. Retrieved 30 March 2018, from
Aripiprazole Uses, Side Effects & Warnings - Drugs.com. (2018). Drugs.com. Retrieved 30
March 2018, from https://www.drugs.com/mtm/aripiprazole.html
Goodwin, G. M., Haddad, P. M., Ferrier, I. N., Aronson, J. K., Barnes, T. R. H., Cipriani, A., ...
& Holmes, E. A. (2016). Evidence-based guidelines for treating bipolar disorder: revised
third edition recommendations from the British Association for
Psychopharmacology. Journal of Psychopharmacology, 30(6), 495-553.
Muneer, A. (2016). The treatment of adult bipolar disorder with aripiprazole: a systematic
review. Cureus, 8(4).

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