Evidence Based Article Writing

Running head: ARIPIPRAZOLE USE 1

ARIPIPRAZOLE FOR TREATING MODERATE TO SEVERE MANIC EPISODES IN

ADOLESCENTS WITH BIPOLAR 1 DISORDER

Student’s Name

University Affiliation

ARIPIPRAZOLE USE 2

Introduction

Aripiprazole is an antipsychotic drug that is usually recommended and exclusively used

in the treatment of bipolar disorder and schizophrenia. The drug can also be used as an add-on

treatment for most depressive disorders and irritability linked to autism. The article contains

guidance for practitioners as they administer aripiprazole to adolescents who suffer from

moderate to severe manic episodes associated with bipolar I disorder. Bipolar disorder is

characterized by fluctuations in moods polarity with manic and major depressive periods

alternatively. It is useful to medical practitioners since it provides a guideline for the

administration of this drug (Muneer 2016). By using the article, medical practitioners will be

able to issue dosing instructions and inform patients of the side effects of the drug when they use

it. It is important to medical nursing since it provides key insights regarding the treatment of

manic episodes in bipolar I disorder patients,

Summary of article

Aripiprazole is the preferred option for treating cases of mania in adolescents suffering

from bipolar I disorder. The drug has a marketing authorization of up to twelve weeks clinicians

are also advised to consider stopping treatment using the drug when usage hits the twelfth week.

The article also suggests that children should be involved in the matters concerning their taking

of drugs and assume responsibility.

The dosing instructions for aripiprazole require that only 10mg per day of the drug be

administered once without considering meals. This is the recommended dosage. However, there

are instances where patients take more than the recommended dosage. As such it is

recommended that the administration of such high doses of the drug should only be administered

ARIPIPRAZOLE USE 3

in exceptional cases albeit under close clinical monitoring. Aripiprazole is packaged in different

weight distribution sizes as tablets and can also be found as an oral solution. The oral solutions

are bioequivalent. The drug's half-life is at least seventy-five hours. The drug has side effects

which rage form fatigue, somnolence and increased heart rate and weight.

Use of information from the article

As a medical practitioner, this information is vital in the treatment of bipolar I patients

who suffer from severe and mild manic episodes. The information initially provides instructions

to clinicians on how they should administer aripiprazole to bipolar patients.

The guideline holds the views of NICE and the views were arrived at after a careful

analysis of the evidence presented. Healthcare professional is therefore required to implement

the article’s findings when they indulge in clinical practices and exercise their judgment. The

guideline, however, does not supersede clinicians’ responsibilities in caring for patients.

Therefore, health professionals are still expected to make decisions that impact positively on the

health care of mental patients.

Strengths of the article

The article is quite significant in disseminating information about the use of aripiprazole

in treating manic episodes in patients. The guideline clearly outlines the instructions and

requirements that determine the administration of aripiprazole. This is very important for health

professionals. Moreover, the guideline in the article advices clinicians on regulating the use of

this drug which has a twelve-week maximum period use.

Weaknesses of the article

ARIPIPRAZOLE USE 4

The article, unfortunately, does not provide sufficient details concerning the methods and

results that were used to make the finding. This is undesirable for an article providing facts about

a medical issue. The use of aripiprazole to treat bipolar I disorder has not been extensively

explored. The drug is known to have many complex issues surrounding its use. It is also common

knowledge that the drug's side effects can be deadly yet the article fails to reveal this unfortunate

reality ("Aripiprazole Uses, Side Effects & Warnings - Drugs.com", 2018).

The article also fails to carry out clinical trials to show the effectiveness of using the

drug. This would be significant since it would allow health practitioners to prove the results of

the findings in the article. The trials would also prove instrumental in showing evidence of how

the drug works in adolescents and encourage research into its use for younger bipolar patients.

I would highly recommend this article to a colleague for analysis and implementation in

their medical practices. This is because the article is quite informative of the guidelines used in

administering patient care to bipolar patients. The article is also quite instructive and advice

medical practitioners on how to deal with young bipolar patients. This makes it quite significant

to health professionals hence recommendable to my colleagues.

Conclusion

Bipolar disorder is a much neglected mental illness, and it has not been researched

extensively. This, therefore, introduces a perception that its treatment should be researched and

improved (Goodwin et al. 2016). The use of guidelines has provided medical practitioners the

opportunity to improve the quality of care by advocating for the implementation of particular

treatment approaches.

ARIPIPRAZOLE USE 5

Therefore, in this article, it is quite important for medical practitioners to consider the use

of aripiprazole in the treatment of manic episodes. By adhering to the laid out guidelines, they

will be able to support patient care to adolescents over the age of thirteen years who suffer from

manic episodes. More importantly, the guideline will assist medical practitioners in ensuring the

treatment plan works efficiently.

ARIPIPRAZOLE USE 6

References

(2018). Dorsetccg.nhs.uk. Retrieved 30 March 2018, from

http://www.dorsetccg.nhs.uk/Downloads/aboutus/medicines-

management/Other%20Guidelines/Aripiprazole%20for%20bipolar%20I%20in%20adoles

cents.pdf

Aripiprazole Uses, Side Effects & Warnings - Drugs.com. (2018). Drugs.com. Retrieved 30

March 2018, from https://www.drugs.com/mtm/aripiprazole.html

Goodwin, G. M., Haddad, P. M., Ferrier, I. N., Aronson, J. K., Barnes, T. R. H., Cipriani, A., ...

& Holmes, E. A. (2016). Evidence-based guidelines for treating bipolar disorder: revised

third edition recommendations from the British Association for

Psychopharmacology. Journal of Psychopharmacology, 30(6), 495-553.

Muneer, A. (2016). The treatment of adult bipolar disorder with aripiprazole: a systematic

review. Cureus, 8(4).

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